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本文收集了22例甲状腺髓样癌,并就其临床和病理特征进行了分析。全部病例均因甲状腺肿块就诊。均无家族史和其他神经内分泌肿瘤证据,且均属散发型。22例中有18例用刚果红染色检测了淀粉样物质的沉积,其中14例呈阳性反应,阳性率为77.8%。免疫组化在该瘤与其他肿瘤的鉴别诊断中有较为理想的作用。免疫组化除降钙素检测恒定阳性外(本组中阳性率为100%),NSE,CgA和Syn阳性率为100%—54%,对肿瘤的诊断有较大的帮助。此外,对影响本瘤预后的因素进行了讨论。
This article collected 22 cases of medullary thyroid carcinoma and analyzed its clinical and pathological features. All cases were diagnosed with thyroid masses. There was no evidence of family history and other neuroendocrine tumors, and all were sporadic. Eighteen of the 22 cases were stained for Congo red for the detection of amyloid deposits, of which 14 were positive and the positive rate was 77.8%. Immunohistochemistry has an ideal role in the differential diagnosis of this tumor and other tumors. Immunohistochemistry In addition to a constant positive detection of calcitonin (positive rate in this group is 100%), NSE, CgA and Syn positive rate was 100% - 54%, a great help in the diagnosis of cancer. In addition, the factors that affect the prognosis of this tumor are discussed.