弥漫性全细支气管炎工藤翔二弥漫性全细支气管炎（ＤＰＢ）在日本是有代表性的难治性呼吸疾病。由本间、山中等提出的本疾病概念至今已经过了四分之一世纪。１９７０年至８０年代前半，这一疾病是处在概念普及和治疗困难的时代。８０年代后半以来，由作者等提出的红霉素疗... Diffuse panbronchiolitis Kudou Shinji’s diffuse bronchiolitis (DPB) is a form of refractory respiratory disease in Japan. The concept of this disease, proposed by Yamamoto and others heretofore, has passed a quarter of a century ago. From 1970 to the first half of the 1980s, the disease was in an age of universalization and treatment difficulties. Since the second half of the 1980s, erythromycin therapy has been proposed by the authors.