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目的:探讨癫痫和T淋巴细胞亚群之间关系。方法:选择全面强直阵挛性和复杂部分性癫痫58例为研究对象,其中口服卡马西平组30例,未服药组28例。健康对照组26例。测定外周血中CD_3、CD_4、CD_8数量,并与对照组比较。结果:全面强直阵挛性癫痫组与复杂部分癫痫组之间,口服卡马西平组与未服药组之间均无显著性差异(P>0.05);癫痫组CD_4、CD_4/CD_8低于健康对照组差异非常显著(P<0.01)。癫痫组CD_3与健康对照组比较差异显著(P<0.05)。结论:癫痫患者存在细胞免疫功能低下,其严重程度与抗癫痫药物卡马西平治疗无关。
Objective: To investigate the relationship between epilepsy and T lymphocyte subsets. Methods: Fifty-eight cases of generalized tonic clonic and complex partial epilepsy were selected as the study subjects, including 30 cases of oral carbamazepine group and 28 cases of non-medication group. Healthy control group of 26 cases. The amount of CD_3, CD_4 and CD_8 in peripheral blood was measured and compared with the control group. Results: There was no significant difference between the full tonic clonic epilepsy group and the complicated partial epilepsy group, oral carbamazepine group and no medication group (P> 0.05). The levels of CD 4, CD 4 / CD 8 in epilepsy group were lower than The difference between the healthy control group was significant (P <0.01). Epilepsy group CD_3 compared with the healthy control group difference was significant (P <0.05). Conclusion: Epilepsy patients have cellular immune dysfunction, the severity of antiepileptic drug carbamazepine treatment has nothing to do.