血管内皮细胞损伤及功能失调是导致动脉粥样硬化的一个重要环节。近年来的研究表明,化学修饰的脂蛋白,尤其是氧化低密度脂蛋白可通过内皮细胞内脂质过氧化损伤,加速泡沫细胞形成以及内皮源性舒张机制障碍等途径而在动脉粥样硬化的发生发展上起关键性的作用。针对氧化低密度脂蛋白的致动脉粥样硬化作用研究颇多,但方法结论不一,有些甚至得出相反的结论。本文就这一问题作一综述。 Vascular endothelial cell damage and dysfunction is an important part of atherosclerosis. In recent years, studies have shown that chemically modified lipoproteins, especially oxidized low-density lipoprotein, can play a role in atherosclerosis through lipid peroxidation injury in endothelial cells, accelerated foam cell formation and endothelial-derived diastolic dysfunction Occurrence of development plays a key role. Atherosclerosis has been studied a lot for oxidized low-density lipoprotein, but the results are mixed and some even come to the opposite conclusion. This article reviews this issue.