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目的:评价膀胱粘膜下浸润注射盐酸氮芥预防膀胱癌术后复发的疗效。方法:对106例(90例非浸润性、16例浸润性)膀胱癌患者行膀胱部分切除术,对其中5例浸润性膀胱癌同时切除邻近肿瘤的膀胱周围组织和区域淋巴结,术中用2mg%盐酸氮芥生理盐水溶液100ml～160ml在所剩余膀胱粘膜下全部浸润注射,术后定期用丝裂霉素C(MMC)膀胱灌注。结果:106例随访6个月～13年,平均9年。无肿瘤复发103例,复发3例,总复发率为2.9%。90例非浸润性癌全部无复发。16例浸润性癌,复发3例,复发率18.75%。结论:膀胱粘膜下浸润注射盐酸氮芥预防膀胱癌术后复发疗效好,降低复发率显著,毒副反应少,临床应用安全可靠。
Objective: To evaluate the curative effect of intravesical instillation of imipenem hydrochloride in preventing postoperative recurrence of bladder cancer. Methods: 106 cases (90 non-invasive, 16 cases of invasive) bladder cancer patients underwent partial partial resection of the bladder, in which 5 cases of invasive bladder cancer adjacent resection of the bladder surrounding tissue and regional lymph nodes, intraoperative use of 2mg % Nitrogenous nitrogen chloride saline solution 100ml ~ 160ml infiltration of the remaining bladder mucosa all infiltration, postoperative with mitomycin C (MMC) bladder perfusion. Results: 106 cases were followed up for 6 months to 13 years, an average of 9 years. No tumor recurrence in 103 cases, 3 cases of recurrence, the total recurrence rate was 2.9%. All 90 non-invasive cancers did not relapse. 16 cases of invasive cancer, recurrence in 3 cases, the recurrence rate was 18.75%. CONCLUSION: Bladder submucosal infiltration of injection of nitrogen mustard hydrochloride in the prevention of bladder cancer recurrence after curative effect is good, reduce the recurrence rate was significant, fewer side effects, clinical safe and reliable.