目的：分析吸入己酮可可碱（ｐｅｎｔｏｘｉｆｙｌｌｉｎｅ，ＰＴＸ，商品名潘通）治疗慢性阻塞性肺疾病（ＣＯＰＤ）患者的疗效。方法：ＣＯＰＤ急性加重期患者 ２９例，随机分为两组：（１）治疗组：ＰＴＸ １００ ｍｇ加入生理盐水 ５ｍｌ经超声雾化吸入；（２）对照组：糜蛋白酶 ５ｍｇ加入生理盐水 ５ ｍｌ超声雾化吸入。均为每日 ２次，疗程 ２周。治疗前后常规检查肺功能、动脉血气、肝肾功能、血浆白细胞介素－８（ＩＬ—８）、超氧歧化酶（ＳＯＤ）、丙二醛（ＭＤＡ）。并观察药物不良反应。结果：治疗组患者治疗后ＩＬ—８、ＭＤＡ均下降，ＳＯＤ明显增高（Ｐ＜０．０１）；对照组ＳＯＤ不升反降，ＭＤＡ不降反升，有显著差异（Ｐ分别＜０．０１和＜０．０５）。对照组治疗后 ＩＬ— ８虽有降低，但下降幅度较治疗组小。治疗组在治疗后 Ｐａ ＣＯ２下降，有显著差异（Ｐ＜ ０． ０１）；两组治疗后 ＰａＯ２、ＳａｔＯ２％均有增高。２组治疗前后ＦＥＶ１、ＦＥＶ１％变化均无显著差异（Ｐ＞０． ０５）。两组患者均未发现肝、肾功能损害。除患者反映口感较苦外，无特殊不良反应发生。结论：ＰＴＸ不但抑制中性粒细胞的趋化、募集，抑制中性粒细胞产生ＩＬ—８，同时能够抑制中性粒细胞释放活 PURPOSE: To analyze the efficacy of pentoxifylline (PTX, trade name Pantone) in the treatment of patients with chronic obstructive pulmonary disease (COPD). Methods: Twenty-nine patients with acute exacerbation of COPD were randomly divided into two groups: (1) treatment group: PTX 100 mg added saline 5 ml inhaled by ultrasonic atomization; (2) control group: chymase 5 mg added saline 5 ml ultrasound aerosol inhalation. 2 times a day for 2 weeks. Before and after treatment, pulmonary function, arterial blood gas, liver and kidney function, plasma interleukin-8 (IL-8), superoxide dismutase (SOD) and malondialdehyde (MDA) And observe the adverse drug reactions. Results: After treatment, the levels of IL-8 and MDA and the content of MDA in the treatment group decreased significantly (P <0.01), while in the control group, And <0.05). Although the control group IL-8 after treatment decreased, but the decline was smaller than the treatment group. The PaCO 2 in treatment group decreased significantly after treatment (P <0.01); PaO2 and SatO2% increased after treatment in both groups. There were no significant differences in FEV1 and FEV1% between the two groups before and after treatment (P> 0.05). Two groups of patients did not find liver and kidney dysfunction. In addition to the patient to reflect the more bitter taste, no special adverse reactions. CONCLUSION: PTX not only inhibits the chemotaxis of neutrophils, recruits and inhibits neutrophil production of IL-8, but also inhibits neutrophil release