论文部分内容阅读
自身免疫性肝炎(autoimmune hepatitis,AIH)是一种由肝脏组织耐受性缺失导致的慢性炎症性疾病.刀豆蛋白A(concanavalin A,Con A)是一种提取自刀豆的植物凝集素.由Con A诱导的肝炎模型常用于研究AIH的动物模型.JAK激酶(janus-activated kinases,JAK)/信号传导与转录激活子(signal transducer and activator of transcription,STAT)信号通路是在该模型中研究比较多的细胞内信号转导通路.该模型中的关键细胞因子IFN-γ、IL-4、IL-12、IL-6及IL-22均可以通过JAK/STAT信号通路发挥作用.本文综述了IFN-γ/STAT1信号通路、IL-4/STAT6信号通路、IL-12/STAT4信号通路参与Con A诱导肝损伤产生的机制,同时综述了IL-6/STAT3信号通路、IL-22/STAT3信号通路对肝损伤的保护作用及可能的机制.
Autoimmune hepatitis (AIH) is a chronic inflammatory disease caused by a loss of liver tissue tolerance.Concanavalin A (Con A) is a phytohemagglutinin derived from polyhedron beans. The hepatitis A model induced by Con A is often used to study the animal model of AIH. JAK / STAT signal pathways are studied in this model More intracellular signal transduction pathway.The key cytokines IFN-γ, IL-4, IL-12, IL-6 and IL-22 in this model all play a role through the JAK / STAT signaling pathway.In this paper, IL-4 / STAT6 signaling pathway and IL-12 / STAT4 signaling pathway are involved in the mechanism of Con A -induced liver injury, and IL-6 / STAT3 signaling pathway, IL-22 / STAT3 signaling Protective effect of pathway on liver injury and possible mechanism.