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目的 :探讨放射性12 5I粒子植入联合化疗治疗进展期胰腺癌的临床价值。方法 :前瞻性随机分组分析放射性12 5I粒子永久植入联合化疗治疗进展期胰腺癌 18例疗效 ,毒副反应及生存率。结果 :放化疗组CR +PR达 38.9% (2 +5 / 18) ,对疼痛控制疗效显著 (77.8%对 5 0 .0 % ) ,与对照组比较有显著性差异 (P <0 .0 5 )。术后 6个月 ,12个月生存率及中位生存时间显著提高。结论 :放射性12 5I粒子植入联合化疗对进展期胰腺癌 ,能控制肿瘤生长 ,缓解疼痛 ,改善患者生活质量。是一种安全有效的肿瘤综合治疗手段。
Objective: To investigate the clinical value of radioactive 125I seed implantation combined with chemotherapy for advanced pancreatic cancer. Methods: A prospective randomized prospective randomized controlled study on the efficacy, toxicity and survival rate of 18 patients with advanced pancreatic cancer treated with radioactive 125I permanent implantation and chemotherapy. Results: The radiotherapy and chemotherapy group had a CR + PR of 38.9% (2 +5 / 18), which had a significant effect on pain control (77.8% vs. 50.0%), which was significantly different from the control group (P <0.05) ). After 6 months, 12 months survival rate and median survival time increased significantly. CONCLUSION: Radioactive 125I seeds combined with chemotherapy for advanced pancreatic cancer can control tumor growth, relieve pain and improve quality of life of patients. Is a safe and effective comprehensive treatment of cancer means.