论文部分内容阅读
和成人一样,儿童胃窦粘膜中存在有幽门弯曲菌(CP)时,常伴有胃炎。单用羟氨苄青霉素可清除CP,但3月后有3/4的病例复发。本文报道羟氨苄青霉素及磺甲硝眯唑合用治疗CP 胃炎的疗效。病人和方法为1988年2月至12月间英国及意大利的患者,受试对象有上腹部疼痛,经胃镜确诊为CP胃炎的32名儿童,其中男性20例,女性12例;年龄6～18(平均12)岁。治疗方法为每日口服羟氨苄青霉素50mg/kg 和磺甲硝咪唑20mg/kg,共6周。治疗前及治疗结束后4周于胃镜下取胃窦粘膜活检,包括镜检、CP 培养及脲酶试验;并收集空腹血做血清CP IgG 抗体、胃蛋白酶原Ⅰ及胃泌素含量检测。结束治疗后6月,10例因反复腹痛,2例为随诊消化性溃疡再复查,其余20例均无症状。
Like adults, gastritis is often associated with the presence of Campylobacter pylori in children’s antral mucosa. Amoxicillin alone cleared CP, but in March, 3/4 of the cases relapsed. This article reports amoxicillin and sulfamethoxazole combined treatment of CP gastritis curative effect. The patients and methods were patients from February to December 1988 in the United Kingdom and Italy. The subjects were those with upper abdominal pain and 32 children diagnosed with CP gastritis by gastroscope, including 20 males and 12 females, aged 6-18 (Average 12) years old. Treatments were daily oral amoxicillin 50mg / kg and sulfamethoxazole 20mg / kg for 6 weeks. Antral mucosal biopsies were taken under gastroscopy four weeks before and after gastroscopy, including microscopic examination, CP culture and urease test; serum CP IgG antibody, pepsinogen Ⅰ and gastrin levels were collected for fasting blood samples. Six months after the end of treatment, 10 cases had recurrent abdominal pain and 2 cases were followed up for peptic ulcer. The remaining 20 cases were asymptomatic.