布鲁氏杆菌能进入细胞内,常引起多种哺乳动物的慢性感染。此属菌能在网状内皮系统的吞噬细胞内生存,而且象分枝杆菌、沙门氏菌、李司德氏菌那样,巨噬细胞抗菌活力的升高是免疫反应的主要特征。鼠尽管不一定是此菌的天然宿主,但能为此菌的细胞内感染提供有用而容易操作的模型。在鼠的实验性结核病和李司德氏菌病中,已证明:巨噬细胞之活化,是一种T-细胞依赖性功能,巨噬细胞在感染部位增殖,单核细胞也从骨髓进入这一部位。从已进行的一些实验看,巨噬细胞似乎也能在鼠的布鲁氏菌感染部位蓄积。除李司德氏菌病外,所有这些感染都有一个共同特征——慢性经过。尽 Brucella can enter the cell, often causing chronic infections in many mammals. This bacterium can survive in phagocytes of the reticuloendothelial system, and like mycobacteria, salmonella, and listeria, the increase in the antibacterial activity of macrophages is a major feature of the immune response. Although not necessarily a natural host to this bacterium, the mouse can provide a useful and easy-to-manipulate model for the intracellular infection of this bacterium. In murine experimental tuberculosis and listeriosis, it has been demonstrated that activation of macrophages is a T-cell dependent function in which macrophages proliferate at the site of infection and monocytes also enter the bone marrow A part. From experiments that have been conducted, it appears that macrophages also accumulate in brucella infections in mice. With the exception of Listeriosis, all of these infections have a common characteristic - chronic passage. Do