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为确定硫酸锌预防性用药对减少儿童感冒的发生,及评估其对减轻感冒症状和持续时间的作用,将200名健康儿童随机分成口服硫酸锌组及安慰剂组。在每7个月研究周期中,每天预防性给予1次硫酸锌或安慰剂糖浆。在感冒发生时药物剂量每天增加到2倍直到感冒症状消失。研究结果显示,锌组的患感冒平均次数明显少于安慰剂组。因感冒而缺课的平均天数在锌组是0.9d,而安慰剂组是1.3d。和安慰剂组相比,锌组患感冒的持续时间较短,而且症状较轻。在2组中不良反应都是轻微的和相似的。研究认为,对预防和治疗儿童感冒,硫酸锌是一种易于管理、安全及耐受良好的可选择药物。
To determine if zinc sulphate prophylaxis would reduce the incidence of childhood colds and assess their effect on reducing the symptoms and duration of cold, 200 healthy children were randomized to oral zinc sulphate and placebo. In each 7-month study period, zinc sulfate or placebo syrup was administered prophylactically once daily. When a cold occurs, the dose of medicine increases twice daily until symptoms of the cold disappear. The results showed that the average number of cold patients in the zinc group was significantly less than the placebo group. The average number of days missed due to a cold was 0.9d in the zinc group and 1.3d in the placebo group. Compared with the placebo group, zinc group suffered a shorter duration of cold and mild symptoms. Adverse reactions were mild and similar in both groups. Studies suggest that zinc sulfate is an easily manageable, safe and well-tolerated alternative to preventing and treating childhood flu.