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[目的]观察天佛参口服液联合化学疗法治疗气阴两虚非小细胞肺癌疗效。[方法]使用随机平行对照方法,将40例住院患者按病志号抽签简单随机分为两组。对照组20例GP方案:健择1000mg/m2+0.09%生理盐水100m L,第1、第8d静滴,顺铂75mg/m2(总量)+0.09%生理盐水250m L,第1、2d静滴。治疗组20例天佛参口服液,20m L/次,3次/d;化疗同对照组。连续治疗4周为1疗程。观测临床症状、瘤灶变化、中医证候、生活质量、细胞免疫功能、不良反应。连续治疗2疗程,判定疗效。[结果]中医证候改善、临床症状改善、CD4+T细胞、NK细胞增加率治疗组均优于对照组(P<0.05);瘤灶变化、生活质量改善、CD3+T细胞、CD4/CD8改善两组均无明显差异(P>0.05)。两组均未出现明显心、肝、肾功能损害,外周血象白细胞、中性粒细胞保护作用、恶心呕吐治疗组明显优于对照组(P<0.05)。[结论]天佛参口服液联合化疗治疗气阴两虚非小细胞型肺癌,疗效满意,无严重不良反应,值得推广。
[Objective] To observe the therapeutic effect of Tianfushen oral liquid combined with chemotherapy on non-small cell lung cancer with deficiency of both qi and yin. [Methods] Using randomized parallel control method, 40 inpatients were randomly divided into two groups randomly according to the patient’s lot number. In the control group, 20 cases of GP regimen were treated with gemcitabine 1000mg / m2 + 0.09% saline 100ml, the first and the eighth day intravenous infusion, the cisplatin 75mg / m2 (total amount) + 0.09% saline 250ml, drop. 20 cases of treatment group Tianfo Shen oral liquid, 20m L / times, 3 times / d; chemotherapy with the control group. Continuous treatment for 4 weeks for a course of treatment. Observation of clinical symptoms, tumor changes, TCM syndromes, quality of life, cellular immune function, adverse reactions. Continuous treatment of 2 courses to determine the efficacy. [Results] The improvement of TCM syndromes, the improvement of clinical symptoms, the increase rate of CD4 + T cells and NK cells in the treatment group were better than those in the control group (P <0.05). The changes of tumor focus, quality of life, CD3 + T cells, CD4 / There was no significant difference between the two groups (P> 0.05). No significant heart, liver and kidney damage occurred in both groups. Peripheral blood leucocytes and neutrophil protection were significantly better than those in the control group (P <0.05). [Conclusion] Tianfo Shen oral liquid combined with chemotherapy in the treatment of non-small cell lung cancer of both genital and qi deficiency has satisfactory curative effect and no serious adverse reactions, which deserves promotion.