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目的研究环境铅暴露的新婚女性血铅水平对临床受孕时间(TTP)的影响。方法用前瞻性队列研究方法,对有环境铅暴露的准备怀孕的210对新婚夫妇建立研究队列,进行基线调查,采集静脉血进行血铅测定,并追踪至临床怀孕,计算TTP,分析血铅水平对TTP的影响。结果210例女性血铅几何均值±标准差为(62.71±2.18)μg/L,平均TTP为2.95个月经周期,随着TTP的延长,受孕率逐渐降低;女性高血铅组(≥100μg/L)和低血铅组(<100μg/L)TTP中位数分别为3.38、2.74个月经周期,TTP分布构成比差异有统计学意义(P<0.05);COX比例风险模型进行多元逐步回归分析显示,女性高、低血铅组受孕力比值(FR)为0.626(95%可信区间0.416～0.941),差异有统计学意义(P<0.05),表明女性血铅≥100μg/L时,受孕力可能下降。结论环境铅暴露对TTP可能有不良影响。
Objective To study the effect of lead exposure on newly diagnosed female blood lead levels on clinical pregnancy time (TTP). METHODS: A prospective cohort study was conducted to establish a cohort of 210 newlyweds who were pregnant with environmental lead exposure and baseline surveys. Blood samples were taken for blood lead determination and follow-up to clinical pregnancy. TTP was calculated and blood lead levels were analyzed Impact on TTP. Results The geometric mean ± standard deviation of blood lead level in the 210 women was (62.71 ± 2.18) μg / L and the average TTP was 2.95 menstrual cycles. With the extension of TTP, the conception rate gradually decreased. In the female high blood lead group (≥100 μg / L ) And low blood lead group (<100μg / L) were 3.38 and 2.74 menstrual cycles, respectively. There was significant difference in the TTP distribution between the two groups (P <0.05). The multivariate stepwise regression analysis of the COX proportional hazard model (FR) was 0.626 (95% confidence interval 0.416-0.941) in female high and low blood lead group, the difference was statistically significant (P <0.05), which showed that when female blood lead level ≥100μg / L, the pregnancy rate May decline. Conclusion Environmental exposure to lead may have adverse effects on TTP.