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1978年Reiner等成功地研制了一种毒性低,渗透组织速度快,体内无代谢作用,人血清半衰期长达6.5～8.6小时的长效注射用的第三代头孢菌素——头孢三嗪。它对临床
In 1978, Reiner et al successfully developed a third generation cephalosporin-ceftriaxone for long-acting injection with low toxicity, high tissue penetration rate, no metabolic effect in vivo, and long half-life of 6.5 to 8.6 hours for human serum. It is clinical