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甲巯丙脯酸是近年来合成的一种口服血管紧张素转换酶抑制剂,主要用于治疗各种类型的高血压,充血性心力衰竭。现将其药物相互作用概述如下。 1.甲巯丙脯酸+双氢克尿塞甲巯丙脯酸的抗高血压机理较为复杂,可减少血管紧张素Ⅰ转变为血管紧张素Ⅱ,从而减轻血管收缩,降低外周阻力为其主要作用;双氢克尿塞可减少血容量,增加钠离子排泄.但其降压作用在很大程
Captopril is an oral angiotensin-converting enzyme inhibitor synthesized in recent years and is mainly used for the treatment of various types of hypertension and congestive heart failure. The drug interactions are summarized below. 1. Captopril + hydrochlorothiazide Captopril antihypertensive mechanism is more complicated, can reduce the conversion of angiotensin Ⅰ to angiotensin Ⅱ, thereby reducing vasoconstriction and reducing peripheral resistance as its main role; hydrochlorothiazide Reduce blood volume, increase sodium excretion, but its antihypertensive effect is very large