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原发性肝细胞癌(Primary hepatic carcinoma,PHC)是世界上最常见且致死率最高的癌症之一。1950年前,不少病理学家曾注意到 PHC 通常发生在患有坏死后性肝硬化的肝脏。故认为肝硬化和 PHC均为病毒性肝炎的最终结果。首先,PHC 通常发生于乙型肝炎病毒(HBV)慢性携带者流行区;而在非流行区 PHC 的发病率则低得多;其次,通过对照病例的研究表明,在 HBV 流行区生活的 PHC 患者中,有90％以上其血中有 HBsAg或高滴度的抗核心抗体。上述标记可被认为是患者业经或现时发生持续性 HBV 感染的证据。而在同一地
Primary hepatic carcinoma (PHC) is one of the most common and lethal cancers in the world. Before 1950, many pathologists have noticed that PHC usually occurs in the liver with necrotizing cirrhosis. So that the liver cirrhosis and PHC are the final result of viral hepatitis. First, PHC usually occurs in the endemic area of chronic carriers of Hepatitis B virus (HBV), whereas in non-endemic areas the incidence of PHC is much lower. Second, studies from control cases show that patients with PHC who live in an endemic area of HBV , More than 90% of their blood HBsAg or high titers of anti-core antibodies. The above markers can be considered as evidence of persistent or current persistent HBV infection in patients. In the same place