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瘙痒是胆汁瘀积的常见症状,原因尚不完全清楚,多数学者认为系胆盐在皮肤神经末梢积聚所致。但此类患者皮肤表面胆盐量与瘙痒间的相关性,并未得到其他研究者的证实。用纯胆盐致皮肤瘙痒仅在人工高浓度条件或用非结合胆盐才能成功,而后者在无瘙痒型肝硬化者占主要地位,在胆汁瘀积者并不存在。自发现消胆胺有解除瘙痒的作用后,有关胆汁瘀积与胆盐有关的理论得以建立。但消胆胺作用并非单一,它因胆盐以外的一些不同成份的吸收而有所不同。有报告消胆胺还可消除真性红细胞增多症及尿毒
Pruritus is a common symptom of cholestasis, the reason is not completely clear, most scholars believe that the bile salts in the skin caused by the accumulation of nerve endings. However, such patients with skin surface bile salt and itch between the correlation has not been confirmed by other researchers. Pruritus caused by pure bile salt only in artificial high concentration conditions or with unconjugated bile salts to succeed, while the latter in the non-pruritic cirrhosis who dominates in the bile stasis who does not exist. Since the discovery of cholestyramine to relieve itch, the theory of bile stasis associated with bile salts was established. However, the role of cholestyramine is not unique, it is due to the bile salt absorption of some different ingredients vary. Have reported cholestyramine can also eliminate polycythemia vera and uremia