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目的探究阿德福韦酯胶囊与苦参素胶囊联合治疗慢性乙型肝炎的临床效果。方法选取慢性乙型病毒性肝炎230例,对照组115例,给予阿德福韦酯10mg/d,口服,连用48周。治疗组115例,在对照组治疗基础上加用苦参素0.3g,3次/d,口服,连用48周。观察两组病毒应答率、生化应答率、HBsAg阴转率、HBeAg阴转率及HBeAg/HBe转换率。结果对照组与治疗组24周时病毒应答率,生化应答率、HBsAg阴转率、HBeAg阴转率、HBeAg/HBe转换率分别为59.1,50.4,1.7,27.8,24.3和75.7,72.2,7.8,49.6,41.7。48周时分别为74.8,66.1,2.6,33.9,27.8和87.8,80.0,11.3,60.0,49.6。结论阿德福韦酯与苦参素胶囊联用能增强抗乙肝病毒的效力,提高治疗慢性乙型肝炎临床疗效。
Objective To investigate the clinical efficacy of adefovir dipivoxil capsule and oxymatrine capsule in the treatment of chronic hepatitis B patients. Methods 230 cases of chronic hepatitis B and 115 cases of control group were given adefovir dipivoxil 10mg / d orally for 48 weeks. Treatment group of 115 cases, in the control group based on the treatment with the addition of matrine 0.3g, 3 times / d, orally, once every 48 weeks. Two groups of virus response rate, biochemical response rate, HBsAg negative conversion rate, HBeAg negative conversion rate and HBeAg / HBe conversion rate were observed. Results The rates of virus response, biochemical response rate, HBsAg negative conversion rate, HBeAg negative conversion rate and HBeAg / HBe conversion rates of the control group and the treatment group were 59.1, 50.4, 1.7, 27.8, 24.3 and 75.7, 72.2, 49.6 and 41.7.48 weeks, respectively, 74.8,66.1,2.6,33.9,27.8 and 87.8,80.0,11.3,60.0,49.6. Conclusion Adefovir dipivoxil and oxymatrine capsules can enhance the efficacy of anti-hepatitis B virus and improve the clinical efficacy of treatment of chronic hepatitis B.