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目的:分析89锶治疗转移性骨肿瘤的临床疗效及其安全性。方法:42例转移性骨肿瘤患者接受了89锶治疗。治疗后定期测定血常规、血生化等指标,随访时间3个月以上。对患者骨痛缓解情况、不良反应和血液学、肝肾功能变化进行观察和评价。结果:42例中有效35例,总有效率83.3%,起效时间2—20 d,缓解持续时间3—14个月。毒性反应主要有轻度可逆性骨髓抑制,血液学毒性小于Ⅱ级。无过敏反应及其他特殊不良反应。对肝肾功能无明显影响。结论:89锶对于转移性骨肿瘤所致的剧烈疼痛有良好的止痛效果,毒副作用小,是提高患者的生存质量的一种有效、安全的治疗方法。
Objective: To analyze the clinical efficacy and safety of 89 strontium in the treatment of metastatic bone tumors. METHODS: Forty-two patients with metastatic bone tumors underwent 89 strontium treatment. After treatment regular determination of blood, blood biochemical and other indicators, follow-up time of 3 months or more. Patients with bone pain relief, adverse reactions and hematology, liver and kidney function changes were observed and evaluated. Results: Of the 42 cases, 35 were effective, the total effective rate was 83.3%, the onset time was 2-20 days and the duration of remission was 3-14 months. Toxicity mainly mild reversible myelosuppression, hematological toxicity less than Ⅱ grade. No allergic reactions and other special adverse reactions. No significant effect on liver and kidney function. CONCLUSIONS: 89 strontium has a good analgesic effect on severe pain caused by metastatic bone tumors with little side effects and is an effective and safe treatment for improving the quality of life of patients.