[目的]探讨二维斑点追踪成像对左心室心肌致密化不全(LVNC)患儿左心室收缩功能的评估价值.[方法]收集本院临床诊断为LVNC并经规范抗心衰治疗后左心室收缩功能改善患儿 27 例(观察组),另外选取同期本院健康体检儿童27例作为对照组.采用二维斑点追踪成像技术检测两组各节段左心室纵向应变(LS)和总体左心室纵向应变(GLS)、各节段圆周应变(CS)和总体左心室圆周应变(GCS)值并比较.[结果]观察组治疗后左心室舒张末期内径(LVEDD)、左心室收缩末期容积(LVESV)显著低于治疗前,而左心室射血分数(LVEF)显著高于治疗前(均P ＜0.05);观察组治疗后左心室舒张末期容积(LVEDV)、LVEDD与对照组比较差异无统计学意义(均P ＞0.05),而 LVEF则显著低于对照组.观察组治疗后左心室GLS和各节段LS、GCS和各节段CS值均显著高于治疗前(均P ＜0.05);观察组治疗后GLS、GCS、各节段CS和4个心尖节段LS均显著低于对照组(均P＜0.05),其余节段LS与对照组比较差异均无统计学意义(均P ＞0.05).治疗后组中25例LVNC患儿 LVEF≥50%,LVEF绝对值较基线至少提高≥10%;2 例 LVNC患儿 LVEF＜50%,LVEF绝对值较基线提高＜10%.随访过程中,观察组治疗后25例LVNC患儿 LVEF≥50%,LVEF绝对值较基线至少提高≥10%;2例LVNC患儿 LVEF＜50%,LVEF绝对值较治疗前未见明显变化.根据改良 ROSS分级,观察组治疗前27例LVNC患儿心功能Ⅳ级,经治疗后Ⅱ级 19例,Ⅰ级6例,Ⅳ级2例.[结论]LVNC患儿经规范抗心衰治疗后左心室收缩功能较前明显改善,但左心室部分节段的收缩仍未恢复正常水平.二维斑点追踪成像可评估LVNC患儿治疗前后左心室整体和局部心肌功能,为诊治LVNC提供参考依据.“,”[Objective]To investigate the value of twodimensional speckle tracking imaging in the assessment of left ventricular systolic function in children with left ventricular noncompaction (LVNC).[Methods]A total of 27 patients with clini cally diagnosed LVNC whose left ventricular systolic function were improved after standard anti heart failure treatment were collected as the observation group.In addition,27 healthy children were selected as the control group.The routine echocardiographic function parameters was examined firstly,then the left ventricular global longitudinal strain (GLS),global circumferential strain (GCS)and segmental longitudinal strain (LS)and circumferential strain (CS)were evaluated by twodimensional speckle tracking imaging.The above parameters between LVNC children (pretreatment and post treatment)and the control group were compared.[Results]After treatment,LVESV (left ventricular endsystolic volume)and LVEDD (Left ventricular enddiastolic diameter)in LVNC children were lower than those before treatment,while LVEF (left ventricular ejection fraction)was higher than that before treatment in LVNC children (all P＜0.05).There were no significant differences in left ventricular enddiastolic volume (LVEDV)and LVEDD between the observation group post treatment and the control group (P＞0.05),while LVEF was significantly lower than the control group.After treatment,the left ventricular GLS,LS,GCS and CS of LVNC children were higher than those before treatment (all P＜0.05).Compared to the control group,GLS,GCS,CS and 4 apical segments of LS decreased in post treatment LVNC children (P＜0.05),however,there was no significant difference of LS for the remaining segments between the control group and LVNC children post treatment (P＞0.05).In the post treatment group of LVNC children,25 patients had LVEF≥50% and the absolute value of LVEF increased by at least ≥10% compared with baseline.There were only 2 patients with LVNC had LVEF＜50% and the absolute value of LVEF increased by＜10% compared with baseline.During the followup period,25 patients in the observation group kept LVEF≥ 50% and the absolute value of LVEF increased by at least ≥ 10% compared with baseline;those two LVNC children with LVEF＜ 50% had no significant changes of the absolute value of LVEF compared with that before treatment.According to the modified ROSS classification,the cardiac function of the 27 HVNC children pretreatment were gradeⅣ.After treatment, the cardiac function of 19 children were grade II,6 children were grade I,and 2 children were gradeⅣ.[Conclusion]Left ventricular systolic function of children with LVNC get improved after standard anti heart failure treatment,even the contraction of left ventricle segment does not return to normal level.Twodimensional speckle tracking imaging can evaluate the left ventricular global and regional myocardial function preand post treatment in children with LVNC,which provides useful reference for diagnosis and treatment of HVNC.