本文报道用微核胞质分裂阻断法研究BSO(丁胱亚磺亚酰胺,Buthione Sulfoximine)对细胞微核率的影响。研究结果表明BSO对正常人外周血淋巴细胞、BCa-P 37人乳腺癌细胞、中国仓鼠V79细胞和中国仓鼠CHO细胞在用药浓度0.1-2mmol/L情况下,微核发生率与未用药组无显著性差异,在~(60)COγ射线照射下,细胞的微核发生率与辐射剂量呈线性关系,当照射合并BSO时,微核发生率明显增加,表示BSO对细胞具有增加电离辐射的损伤作用。 This paper reports the effect of BSO (Buthione Sulfoximine) on the micronucleus rate of cells using micronuclear cytokinesis blocking method. The results showed that when BSO was applied to normal human peripheral blood lymphocytes, BCa-P 37 human breast cancer cells, Chinese hamster V79 cells, and Chinese hamster CHO cells at a drug concentration of 0.1-2 mmol/L, the incidence of micronucleus and non-drug group were not found. Significant difference, in the ~ (60) CO γ-ray irradiation, the micronucleus rate of cells and the radiation dose was linear, when the radiation combined with BSO, micronucleus incidence increased significantly, indicating that BSO on cells with increased ionizing radiation damage effect.