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Tinorldine(一种非固醇类的抗炎药物)对于由抗坏血酸或NADPH诱导的大鼠肝微粒体的脂类过氧化反应有很强的抑制作用,同时可防止细胞色素P-450及膜结构的破坏。线粒体是一种富有多不饱和脂酸的膜性细胞器,而且线粒体的正常功能依赖于膜结构的高度完整性;因此线粒体是很容易受到脂质过氧化反应的影响。已经证明,亚铁离子,抗坏血酸,谷胱甘肽或NADPH诱导的过氧化反应的过程中,线粒体遭到溶解及功能破坏。本文叙述Tinoridine对抗坏血酸诱导的鼠肝线粒体脂质过氧化反应的作用,并从形成的丙二醛的磷脂含量之间的量的关系研究脂质过氧化反应的
Tinorldine, a non-steroidal anti-inflammatory drug, has a potent inhibitory effect on lipid peroxidation in rat liver microsomes induced by ascorbic acid or NADPH and at the same time prevents cytochrome P-450 and membrane-associated damage. Mitochondria are membranous organelles rich in polyunsaturated fatty acids, and the normal function of mitochondria depends on the high degree of integrity of the membrane structure; mitochondria are therefore susceptible to lipid peroxidation. It has been demonstrated that mitochondria are lysed and functionally disrupted during ferrous ions, ascorbate, glutathione or NADPH-induced peroxidation. This article describes the effect of Tinoridine on ascorbate-induced rat liver mitochondrial lipid peroxidation and the relationship between the amount of phospholipid formed from the malondialdehyde content of lipid peroxidation