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作者指出,Pasvol等曾报道含胎儿血红蛋白(HbF)的红细胞对恶性疟原虫的抗力比含成人血红蛋白(HbA)的红细胞更大的观察结果,提示了产后1个月内,尤其在HbF产量降低较正常人慢的β-地中海贫血携带者,对恶性疟有抗力的机理。作者研究了患同形合子β-地中海贫血的2例,于2年前已切除了脾脏的4岁和6岁儿童,定期输血治疗,平均血红蛋白8克/100毫升,经输血感染三日疟原虫,对三日疟原虫
The authors note that Pasvol et al. Reported that HbF-containing erythrocytes had a greater resistance to P. falciparum than erythrocytes containing adult hemoglobin (HbA), suggesting that within one month postpartum, especially in HbF, the decrease in HbF production Normal human β-thalassemia carriers, the mechanism of resistance to falciparum malaria. The authors studied 2 patients with homozygote β-thalassemia, 4-year-old and 6-year-old children who had spleens removed 2 years ago and received regular blood transfusions with a mean hemoglobin level of 8 g / 100 mL. Transfusions of P. falciparum, Against Plasmodium malariae