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菸酰胺(Nicotinamide)为辅酶Ⅰ和铺酶Ⅱ的组成部分,在生物氧化过程中起递氢作用。自1938年分离出菸酰胺纯品后,曾进行了广泛的药理研究。菸酰胺对心血管机能有显著作用,增强离体蛙心收缩力,减轻电刺激离体兔心引起的心室顫动,增加在位猫心输出量,大剂量略降低犬血压;给大白鼠腹腔注射菸酰胺500毫克/公斤,12小时后肝细胞内辅酶Ⅰ浓度增加7倍;菸酰胺降低大肠杆菌内毒素致死率,提高异菸肼致惊厥剂量;菸酰胺使谷-草转氨酶活性降低,减轻四氯化碳对肝脏的损害。本文研究其对电刺激、氯化鋇、乌头硷和肾上腺素所致心律失常的影响。
Nicotinamide is a component of Coenzyme I and II, which acts as a hydrogen donor during biooxidation. Since the isolation of pure nicotinamide in 1938, extensive pharmacological studies have been conducted. Niacinamide has a significant effect on cardiovascular function, enhancing the contractility of isolated frog hearts, reducing electrical stimulation of ventricular fibrillation induced by isolated rabbit hearts, increasing the cat’s cardiac output, and slightly lowering dog’s blood pressure at high doses; Nicotinamide 500 mg/kg was injected. After 12 hours, the concentration of coenzyme I in hepatocytes increased by 7-fold; nicotinamide reduced the endotoxin lethality of E. coli and increased the dose of convulsant induced by isoniazid; nicotinamide decreased the activity of trough-grass aminotransferase, reducing Carbon tetrachloride damages the liver. This article investigates the effects of electrical stimulation, cesium chloride, aconite and epinephrine on arrhythmias.