两种化疗药物的联合、早期、局部强化治疗对于保留视网膜母细胞瘤患者眼球的影响

来源 :世界核心医学期刊文摘.眼科学分册 | 被引量 : 0次 | 上传用户:ABCDEFGHIJKLMN100083
下载到本地 , 更方便阅读
声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架
论文部分内容阅读
PURPOSE: To evaluate vincristine and carboplatin with intensive focal treatments in the management of intraocular retinoblastoma. DESIGN: Noncomparative, retrospective interventional case series. METHODS: Setting: Institutional. Patient population: Sixteen patients (11 bilateral, 5 unilateral) with intraocular retinoblastoma. Interventional procedures: Patients were treated with eight courses of vincristine and carboplatin. Intensive focal treatments were administered after two courses of chemotherapy. Main outcome measures: Avoidance of external beam radiotherapy (EBRT) and eye survival. RESULTS: Twenty eyes (74.1% ) were classified as Reese-Ellsworth Group V. All eyes responded to chemotherapy. With a median follow-up of 23 months (range 10 to 33 months) and amedian of 5.5 focal treatments per eye (range 0 to 19 treatments), ocular survival was 81% . Eight eyes (30% ) in five patients received EBRT. CONCLUSIONS: Vincristine and carboplatin combined with intensive focal treatments is an effective regimen for patients with intraocular retinoblastoma. This treatment regimen has outcomes comparable to those of more toxic regimens and merits further evaluation. METHODS: Setting: Institutional. Patient population: Sixteen patients (11 bilateral, 5 unilateral) with intraocular retinoblastoma. Interventional Intensive focal treatments were administered after two courses of chemotherapy. Main outcome measures: Avoidance of external beam radiotherapy (EBRT) and eye survival. RESULTS: Twenty eyes (74.1%) were classified as a Reese-Ellsworth Group V. All eyes responded to chemotherapy. With a median follow-up of 23 months (range 10 to 33 months) and a median of 5.5 focal treatments per eye (range 0 to 19 treatments), ocular survival was 81% Eight eyes (30%) in five patients received EBRT. CONCLUSIONS: Vincristine and carboplatin combined with intensive focal treatment is an effective regimen for patients with intraocular retinoblastoma. This treatment regimen has outcomes comparable to those of more toxic regimens and merits further evaluation.
其他文献
这要取决于你在哪里。如果是在有丰富的可食用植物和动物的自然环境中,擅长数学、逻辑原理和书写等技能,几乎没有多大用处。相反,你需要的是狩猎、选择能食用的植物、盖房子
当前我国积极发展船舶和海上平台的生产,对于如何选择船用空调与制冷系统的热交换管的材料是一个关键。本文详细介绍了90/10铜—镍—铁合金在海水冷却系统中呈现的优越性以及
引言 关于海底沉积物声传播速度的测量方法,是多种多样的。为了尽可能减少样品的扰动和所处环境的差异,以获得可靠的测量数据,应采用现场测量技术。据报道,国外已开展这方面
母语迁移是影响二语习得的一个重要因素。从语音、词汇、语法及文化等层面分析二语习得中的母语迁移现象,调查二语习得过程中语言迁移的特点,分析母语的语言学习经历对英语学
今年的情人节因为紧随过年因而难免显得匆忙,3·14白色情人节便更让人期待。其实不仅是情人节,即使放在平时,爱情也需要细心呵护与经营,我们需要时不时地为爱情做些功课,比如了解自己的依恋风格,了解恋人的依恋模式,让我们在亲密关系中跳一支独特的双人舞。  小测试:了解你们的依恋风格  以下的描述哪些最符合你的感受?请在符合描述的项目上画钩。( △=1,○=2,□=3)  1 我常担心伴侣并不是真的爱我,
近年来,土畜产总公司为改进出口商品包装,引进了日本佛列斯克(FRESCO)包装新技术。它对我国出口土特产品、羽绒制品等,具有防潮、防霉、防虫和保质、保鲜的功能;能缩小包装
目的分析自身免疫性胰腺炎(AIP)胰腺自身及胰腺外器官受累的CT表现特点,提高对AIP的诊断水平。方法选择经临床诊断为AIP的9例患者,其中男性6例,女性3例;年龄52~63岁,平均年龄
设计手术,暴露囊状动脉瘤,必须考虑到以下诸方面.基本解剖原则一、动脉瘤多起自载瘤动脉的分支部位,即在载瘤动脉的侧支,如颈内动脉分出后交通动脉处;或在某一主干分叉部位,
白纹伊蚊广州株与北京株、成都株与合肥株进行杂交和反交,其孵化率在60 .1、84.4拓之间,与亲代无明显差别.大多数孵育卵放入水中第1天,卵开始孵化,5天内孵化完毕.杂交、反交
一、临床医学研究的特殊性临床医学研究与基础医学研究的最大不同点,就是主客观条件复杂,难于控制,试验结果也不易恒定。这种矛盾的产生在很大 First, the special nature