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目的:探讨女性不孕及流产患者与自身5种免疫抗体的相关性。方法:采用金标免疫斑点法检测247例不孕及流产患者血清抗精子抗体(AsAb)、抗子宫内膜抗体(EMAb)、抗绒毛膜促性腺激素抗体(hCGAb)、抗滋养层细胞膜抗体(ATA)及抗透明带抗体(AZPA)。选择75例正常妊娠妇女作为对照组,比较两组患者这5项抗体的阳性率。结果:不孕流产组AsAb、EMAb、hCGAb、ATA、AZPA的阳性率分别为47.4%、49.8%、22.7%、23.9%、29.9%,明显高于对照组(5.3%、5.3%、4.0%、2.7%、4.0%),差异均有统计学意义(P<0.05)。结论:AsAb、EMAb、hCGAb、ATA、AZPA与不孕及流产有密切相关性,检测这5项抗体对不孕及流产的病因诊断有重要意义。
Objective: To investigate the correlation between female infertility and spontaneous abortion and their own five kinds of immune antibodies. Methods: Serum anti-sperm antibody (AsAb), anti-endometrial antibody (EMAb), anti-human chorionic gonadotropin (hCGAb) antibody and anti-trophoblast antibody ATA) and anti-zona pellucida antibody (AZPA). 75 normal pregnant women were selected as the control group, and the positive rates of these 5 antibodies were compared between the two groups. Results: The positive rates of AsAb, EMAb, hCGAb, ATA and AZPA in infertility group were 47.4%, 49.8%, 22.7%, 23.9% and 29.9% respectively, which were significantly higher than those in control group (5.3%, 5.3%, 4.0% 2.7%, 4.0%), the differences were statistically significant (P <0.05). Conclusion: AsAb, EMAb, hCGAb, ATA and AZPA are closely related to infertility and miscarriage. The detection of these five antibodies is of great significance in the diagnosis of infertility and abortion.