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本文对27例经肾活检证实的AIN分析其病因、临床表现、形态学所见及预后。病人及方法 27例AIN病人,均经肾活检证实。男16,女11,平均年龄49岁(16～79岁);平均随访18个月(1～84个月)。除1例外,所有病人均有急性肾衰。分析临床资料时特别注意感染及用药史。肾活检标本用光镜及免疫荧光检查。结果病因:15例为药物,9例为感染,3例原因未明。除皮疹主要见于药物诱发者外,不同病因组的表现均相似。少尿14例,有发烧、皮疹、关节痛典型三联征者仅4例。血嗜酸粒细胞增高10例,蛋白尿19例(<1.5g/24小时),无1例有肾病综合征。组织学所见肾间质以淋巴细胞、浆细胞浸润为主。轻度间质纤维化16例、中度8例(其中2例肾功能未恢复正常)。大多数病人肾小管变性
In this paper, 27 cases of AIN confirmed by renal biopsy analysis of its etiology, clinical manifestations, morphological findings and prognosis. Patients and Methods 27 cases of AIN patients, confirmed by renal biopsy. Male 16, female 11, average age 49 years (16 to 79 years); average follow-up 18 months (1 to 84 months). With the exception of 1, all patients had acute renal failure. Special attention to the history of infection and medication when analyzing clinical data. Renal biopsy specimens with light microscopy and immunofluorescence. Etiology: 15 cases were drug, 9 cases were infected, and 3 cases were unknown. Except rash mainly seen in drug-induced outside, the performance of different etiologies were similar. 14 cases of oliguria, fever, rash, joint pain typical triad only 4 cases. Elevated blood eosinophilia in 10 cases, proteinuria in 19 cases (<1.5g / 24 hours), no case of nephrotic syndrome. Histology showed that the renal interstitium to lymphocytes, plasma cell infiltration. Mild interstitial fibrosis in 16 cases, moderate in 8 cases (2 cases of renal function did not return to normal). Tubular degeneration in most patients