尿道下裂是男性泌尿生殖系统最常见畸形之一 ,发病原因仍不清楚。近年来 ,由于外科技术和器械的进步 ,治疗效果明显改观 ,但同时也发现发生率有上升趋势[1] ,因此人们对尿道下裂的发病原因也更加关注。人们试图从分子学水平揭示先天性发育畸形疾病的发生 ,以便从其发生上进行干 Hypospadias is one of the most common deformities of the male genitourinary system, and the cause of the disease is still unclear. In recent years, due to advances in surgical techniques and instruments, the therapeutic effect has obviously improved, but also found that the incidence has increased [1], so people are more concerned about the causes of hypospadias. People try to reveal the occurrence of congenital malformations from the molecular level in order to carry out their