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目的分析硫酸镁、硝苯地平和酚妥拉明联合治疗妊娠期高血压综合征(妊高征)的临床疗效。方法选取2012年4月—2014年4月鄱阳县人民医院收治的妊高征患者78例,随机分为对照组和观察组,各39例。对照组患者给予硫酸镁治疗,观察组患者给予硫酸镁、硝苯地平和酚妥拉明联合治疗,均以7 d为1个疗程。比较两组患者临床疗效和围生期并发症发生情况。结果观察组患者总有效率为94.9%,高于对照组的79.5%(P<0.05);观察组围生期并发症发生率为5.2%,低于对照组的28.2%(P<0.05)。结论硫酸镁、硝苯地平和酚妥拉明联合治疗妊高征疗效确切,可有效控制患者血压,减少围生期并发症的发生,改善妊娠结局。
Objective To analyze the clinical efficacy of magnesium sulfate, nifedipine and phentolamine in the treatment of pregnancy induced hypertension (PIH). Methods 78 patients with PIH admitted in Poyang County People’s Hospital from April 2012 to April 2014 were randomly divided into control group and observation group, with 39 cases in each. Patients in the control group were treated with magnesium sulfate. Patients in the observation group were treated with magnesium sulfate, nifedipine, and phentolamine, all of which were given a course of treatment for 7 days. The clinical efficacy and perinatal complications of the two groups were compared. Results The total effective rate in observation group was 94.9%, which was higher than that in control group (79.5%, P <0.05). The incidence of perinatal complications in observation group was 5.2%, which was lower than that in control group (28.2%, P <0.05). Conclusion Combination therapy of magnesium sulfate, nifedipine and phentolamine has definite therapeutic effect on PIH, which can effectively control the blood pressure, reduce the occurrence of perinatal complications and improve the pregnancy outcome.