利用杂交瘤(Hybridoma)技术生产单克隆抗体(monoclonal antibody,简称 Mc Ab)是近年来免疫学上的一项重大突破。自从1975年 kohler 和 Milstein 首次报道以来,此技术在国外发展很快,短短数年时间,几乎已渗透到一切可应用免疫学方法进行研究的领域。国内于1979年引进,也已取得不少成绩。本文结合文献复习作一简介。 The production of monoclonal antibodies (Hybrid Abs) using monoclonal antibodies (McAbs) is a major immunological breakthrough in recent years. Since the first report by Kohler and Milstein in 1975, this technology has been developed rapidly abroad. In just a few short years, it has infiltrated almost all fields where immunological methods can be applied for research. Domestic introduction in 1979, has also made a lot of achievements. This article combines the literature review for a brief introduction.