所有组织具有移植抗原,当个体之间移植时,除在某些“特殊”无血管或缺乏淋巴液部位外,必然引出最后移植物排斥的免疫学反应。作者的最初实验是为了确定牙齿是否有抗原和能否引出移植免疫。在1958年,用兔子进行异体牙移植实验,得到牙移植抗原的证据,又应用近亲繁殖的鼠,以Mann等的皮肤移植分级技术来测定牙移植的抗原性。除角膜和软骨外,牙与皮肤、肾脏和大多数组织或器官比较,有较弱的抗原性。钙化牙组织能引出可测量的移植免疫,但牙髓和牙周膜是牙移植抗原的主要来源或至少是免疫反应的最初目标。异体牙移植可引起两个方面明确的免疫性:对牙齿软组织相对强 All tissues have a transplanted antigen, and when transplanted between individuals, an immunological reaction that ultimately leads to rejection of the graft is inevitable, except for certain “special” avascular or lymphoid sites. The author's initial experiment was to determine if the tooth had an antigen and whether it would elicit a transplant immune response. In 1958, allogeneic dental transplantation experiments were performed on rabbits to obtain evidence of dental transplants. The inbred mice were also used to determine the antigenicity of the dental transplants on the basis of the skin grafting technique of Mann et al. In addition to cornea and cartilage, teeth have weaker antigenicity than skin, kidney and most tissues or organs. Calcified tooth tissue can elicit measurable transplant immunity, but pulp and periodontal ligament are the main sources of dental transplant antigens or at least the primary target of an immune response. Allogeneic dental transplantation can cause two clear aspects of immunity: the relatively strong teeth and soft tissue