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为探讨FⅧ基因BcⅠ限制性内切酶多态性位点在云南省人群中的诊断价值,应用PCR技术及PAGE分离技术获得云南省傣、彝、汉族人群的多态信息量(polymorphic informative con-tent,PIC),其中傣族人的PIC为0.6435,明显高于汉族人的PIC 0.4190,显著高于彝族人PIC0.3641,这充分显示了FⅧBclⅠ多态现象的民族差异性及该分子遗传标志的应用价值。
To investigate the diagnostic value of FⅧ gene BcⅠ restriction endonuclease polymorphism in Yunnan population, polymorphic informative con- tents in populations of Dai, Yi and Han in Yunnan Province were determined by PCR and PAGE The PIC of Tai people was 0.6435, which was significantly higher than PIC 0.4190 of Han people and significantly higher than PIC0.3641 of Yi people, which fully demonstrated the national differences of FⅧBcl Ⅰ polymorphism and the application of the molecular genetic markers value.