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目的观察早期应用微生态制剂对极低出生体重儿黄疸、喂养、生长以及免疫功能的影响。方法我院NICU收治的生后24h内极低出生体重儿84例,随机分为观察组46例,对照组38例。观察组生后4h内开始口服或鼻饲胃管服用妈咪爱0.5g,2次/d,连用14d。观察两组达到高胆红素血症标准的人数,以及生后24h、5d总胆红素值;喂养不耐受人数;生后5d生理性体重下降及1个月体重增长情况;生后1个月免疫学指标。并加以对比。结果24h内血清胆红素比较无统计学意义(P>0.05),治疗5d后观察组血清总胆红素明显低于对照组(P<0.05),观察组出现高胆红素血症人数明显低于对照组(P<0.05);观察组喂养不耐受出现例数明显低于对照组(P<0.01);观察组生后5d体重下降的克数低于对照组(P<0.05),1个月时体重增长克数高于对照组(P<0.01);观察组IgA水平较对照组明显增加(P<0.05),但IgG及IgM含量与对照组比较差异无统计学意义(P>0.05)。结论早期应用微生态制剂能降低血清胆红素水平,对预防极低出生体重儿高胆红素血症有一定作用;能提高喂养的耐受性,有利于患儿生长发育;对极低出生体重儿的肠道功能及免疫功能有明显影响,能增加免疫球蛋白IgA水平,从而促进体液免疫的发展。
Objective To observe the effect of early application of probiotics on jaundice, feeding, growth and immune function in very low birth weight infants. Methods 84 cases of very low birth weight infants admitted to NICU in our hospital were randomly divided into observation group (46 cases) and control group (38 cases). Observation group within 4h after birth oral or nasogastric tube taking Mommy love 0.5g, 2 times / d, once every 14d. The number of patients who reached the standard of hyperbilirubinemia and the total bilirubin 5 days after birth were observed; the number of people who were intolerant to feeding; the physiological weight loss and body weight gain at 5 days after birth; Months of immunological indicators. And contrast. Results There was no significant difference in serum bilirubin within 24 hours (P> 0.05). After 5 days of treatment, serum total bilirubin in observation group was significantly lower than that in control group (P <0.05). The number of hyperbilirubinemia in observation group was significantly higher (P <0.05). The incidence of feeding intolerance in the observation group was significantly lower than that in the control group (P <0.01). The weight loss in the observation group at 5 days after birth was lower than that in the control group (P <0.05) (P <0.01). The level of IgA in the observation group was significantly higher than that in the control group (P <0.05), but the levels of IgG and IgM in the observation group were not significantly different from those in the control group (P> 0.05). Conclusion Early application of probiotics can reduce the level of serum bilirubin, to prevent very low birth weight children with hyperbilirubinemia have a role; can improve feeding tolerance, is conducive to the growth and development of children; very low birth Intestinal children with weight function and immune function have a significant impact, can increase the level of IgA, thereby promoting the development of humoral immunity.