有效的抗真菌效应需要不同的免疫机制。树突状细胞可以特异性地解码真菌相关信息,激活不同类型的Th细胞免疫反应。树突状细胞通过不同的识别受体吞噬烟曲霉菌的孢子和菌丝,不同的受体又可启动不同的下游信号,从而影响细胞因子的产生和共刺激分子的表达。过继性转移不同类型的树突状细胞可激活保护性或非保护性Th细胞,最终影响侵袭性曲霉菌感染的结局。注入真菌冲击或RNA转染的树突状细胞则能促进宿主抗真菌的Th1型反应。 Effective antifungal effects require different immune mechanisms. Dendritic cells can specifically decode fungal-related messages and activate different types of Th-cell immune responses. Dendritic cells engulf the spores and mycelium of Aspergillus fumigatus through different recognition receptors, and different receptors can activate different downstream signals, thereby affecting the production of cytokines and the expression of costimulatory molecules. Adoptive transfer of different types of dendritic cells activates protective or non-protective Th cells, eventually affecting the outcome of invasive Aspergillus infections. Dendritic cells infused with fungal shock or RNA transfection can promote host antifungal Th1 responses.