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目的探讨喹诺酮类药物临床用药在儿童中常见的不良反应,并提出减少不良反应发生的相应措施。方法选取本院2012年1月至2013年1月应用喹诺酮类药物治疗的细菌感染患儿1120例为研究对象,观察患儿用药后不良反应情况,并采取及时的处理措施。结果 1120例患儿中喹诺酮类药物产生不良反应的患儿有140例,不良反应率为12.5%,其中神经系统反应45例(32.14%),全身发热15例(10.71%),头晕14例(10.00%),头痛11例(7.86%),面色苍白5例(3.57%),呼吸系统反应48例(34.29%),胸闷25例(17.86%),呼吸急促23例(16.43%),消化系统反应47例(33.57%),恶心21例(15.00%),呕吐15例(10.71%),食欲下降10例(7.14%)。所有患儿经及时治疗及护理后不良反应症状均消失。结论喹诺酮类药物在使用过程中不良反应发生率较高,通过对患儿采取相应的预防策略可降低患儿不良反应发生率,提高患儿耐受性及治愈率。
Objective To investigate the common side effects of quinolones in children and to provide corresponding measures to reduce the adverse reactions. Methods A total of 1120 children with bacterial infection treated with quinolones were selected from January 2012 to January 2013 in our hospital. The adverse reactions were observed after treatment and the timely treatment measures were taken. Results 140 children with adverse reactions of quinolones were found in 1120 children with adverse reaction rate of 12.5%, of which 45 (32.14%) were nervous system reaction, 15 (10.71%) were systemic fever and 14 were dizziness Headache in 11 cases (7.86%), pale in 5 cases (3.57%), respiratory reaction in 48 cases (34.29%), chest tightness in 25 cases (17.86%), shortness of breath in 23 cases (16.43%), digestive system There were 47 cases (33.57%) responded to nausea, 21 cases (15.00%) were nausea, 15 cases (10.71%) vomited and 10 cases (7.14%) appetite decreased. All children with symptoms and adverse reactions after treatment and care disappeared. Conclusions Quinolones have a high incidence of adverse reactions during the course of their use. Adopting appropriate preventive strategies can reduce the incidence of adverse reactions and improve the children's tolerance and cure rate.