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目的:通过研究益气养血温阳方对泻药性便秘大鼠结肠SP、NOS-1含量的影响,阐明益气养血温阳方治疗泻药性便秘的机制。方法:将60只SD大鼠随机分为空白对照组、阳性对照组、模型组、益气养血温阳方低、中、高剂量组。阳性对照组、模型组、益气养血温阳方低、中、高剂量组给予大黄建立便秘大鼠模型,阳性对照和益气养血温阳方低、中、高剂量组按剂量给予药物治疗2周,取大鼠结肠组织,试剂盒检测SP、NOS-1含量。结果:益气养血温阳方高剂量组对模型大鼠结肠组织中SP含量改变有显著差异(P<0.05),低、中、高剂量组对模型大鼠结肠组织中NOS-1含量改变有显著差异(P<0.05)。结论:益气养血温阳方通过改变SP、NOS-1含量,促进结肠运动,起到治疗便秘的作用。
Objective: To study the effect of Yiyang Yangxue yangyang Recipe on the content of SP and NOS-1 in the colon of laxative constipation rats and to elucidate the mechanism of Yiyang Yangxueyangyang recipe in treating laxative constipation. Methods: Sixty SD rats were randomly divided into blank control group, positive control group, model group, YQYYYYYY low, middle and high dose groups. The positive control group, model group, Yiqi YangxueYangYangFang low, middle and high dose group were given rhubarb to establish constipation rat model, the positive control and yiqi nourishing yangYangFang low, middle and high dose group according to dose administration Treatment for 2 weeks, take the rat colon tissue, kit detection of SP, NOS-1 content. Results: The Yiqi Yangxue yangyangfang high-dose group had significant difference (P <0.05) in the content of SP in the colon of the model rats, and the content of NOS-1 in the model rats There was a significant difference (P <0.05). Conclusion: Yiyang Yangxue yin yang can change constipation by changing the contents of SP and NOS-1 and promoting colon movement.