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在已发生动脉粥样硬化的患者,心血管功能的保持在于能否使动脉粥样硬化消退或延缓其进展速度,以及促使出现足够的侧枝循环.实验性动脉粥样硬化的诱发和消退在许多实验动物,喂饲胆固醇和脂肪、化学或机械损伤动脉内膜,能够诱发动脉粥样硬化.停止脂肪和胆固醇喂食、给予降脂血和抗血小板治疗,能够使这些实验诱发的动脉粥样病变消退.在实验动物,动脉病变的定量和定性消退,可由动脉标本的大体病理和组织化学检查得到可靠的评价,恒河猴的研
In patients with atherosclerosis, cardiovascular function is maintained by whether or how to reverse or delay the progression of atherosclerosis and to promote adequate collateral circulation.The induction and resolution of experimental atherosclerosis are among the many Experimental animals, fed with cholesterol and fat, chemically or mechanically damaged the intima of the arteries, can induce atherosclerosis. Cessation of fat and cholesterol feeding, administration of hypolipidemic and antiplatelet medications can subside these experimental-induced atherosclerosis In experimental animals, quantification and qualitative regression of arterial lesions were reliably assessed by gross pathology and histochemical examination of arterial specimens,