研究以焦性没食子酸衍生物2,3,4-三羟基苯甲酸为原料经过甲基化、水解、酸化和精制成2,3,4-三甲氧基苯甲酸。研究结果表明,甲基化的最佳条件:硫酸二甲酯与原料的物质的量比为4∶1;催化剂用量为原料质量的5%。精制产品经IR和1HNMR确认了结构,产品质量用HPLC分析,纯度为99.54%。 In this study, pyrogallic acid derivatives 2,3,4-trihydroxybenzoic acid was methylated, hydrolyzed, acidified and purified to 2,3,4-trimethoxybenzoic acid. The results showed that the optimum conditions for methylation were as follows: the molar ratio of dimethyl sulfate to raw material was 4:1; the amount of catalyst was 5% of the mass of raw materials. The purified product was confirmed by IR and 1HNMR. The quality of the product was analyzed by HPLC with a purity of 99.54%.