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目的探讨盐酸二甲胺四环素治疗牙周炎的临床疗效。方法选取2009年5月—2013年5月长子县人民医院收治的牙周炎患者180例,按随机数字表法将患者分为观察组与对照组,各90例。对照组患者予以甲硝唑棒治疗,观察组患者予以盐酸二甲胺四环素治疗。观察两组患者治疗前后出血指数、牙槽骨高度变化、附着丧失情况、临床疗效、复发情况及不良反应发生情况。结果术前两组患者附着指数、出血指数、牙槽骨高度比较,差异无统计学意义(P>0.05);术后观察组患者附着指数、出血指数、牙槽骨高度小于对照组(P<0.05);观察组患者附着获得、牙槽骨高度差值大于对照组(P<0.05);观察组患者总有效率高于对照组(P<0.05);观察组患者复发率低于对照组(P<0.05);观察组患者不良反应发生率低于对照组(P<0.05)。结论二盐酸二甲胺四环素治疗牙周炎的临床效果显著,可较快地改善患者症状,降低复发率,且不良反应小。
Objective To investigate the clinical effect of minocycline hydrochloride on periodontitis. Methods From May 2009 to May 2013, 180 cases of periodontitis were treated in Changzixian People’s Hospital. According to the random number table, the patients were divided into observation group and control group, 90 cases each. Patients in the control group were treated with metronidazole rods, and patients in the observation group were treated with minocycline hydrochloride. The bleeding index, alveolar bone height change, attachment loss, clinical efficacy, recurrence and adverse reactions of two groups were observed before and after treatment. Results There was no significant difference in attachment index, hemorrhage index and alveolar bone height between the two groups before operation (P> 0.05). The attachment index, hemorrhage index and alveolar bone height in postoperative observation group were less than those in control group (P < 0.05). The difference between the observation group and the control group was more than that of the control group (P <0.05). The total effective rate of the observation group was higher than that of the control group (P <0.05), and the recurrence rate of the observation group was lower than that of the control group P <0.05). The incidence of adverse reactions in the observation group was lower than that in the control group (P <0.05). Conclusion Minocycline dihydrochloride has a significant clinical effect on periodontitis. It can quickly improve the symptoms and reduce the recurrence rate with little adverse reaction.