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化学仿生一般认为是用化学方法模拟生物体内的反应,并利用这些方法简化合成步骤和提高合成收率,为生产服务。1979年,Breslow发表的“仿生化学”一文中指出仿生化学是有机化学的一个分支,并试图模拟自然界的反应和酶的过程作为改进有机合成的一种手段。近年来发展很迅速的生物模拟多烯环合为甾体提供了不少全合成路线。它突破了一般全合成的一步一个环的合成过程,而是由具有适当定位的反式烯键的直链化合物一步立体专一性地形成几个环,这不仅有理论上的意义,而且在实用上也将具有极大的价值。胆固醇及其代谢产物是生命过程中的基础物质之一,这已早为人们所共知。而开始于乙酸离子的胆固醇的生物合成则是当代化学中最重要的成就之一(图1)。整条路线之中,角鲨烯经酶
Chemical biomimetic is generally considered to be a chemical method to simulate the reaction in vivo and to use these methods to simplify the synthesis steps and increase the yield of synthesis for the production of services. In 1979, Breslow’s article, Bionics, pointed out that biomimetic chemistry is a branch of organic chemistry and attempts to mimic natural reactions and enzymatic processes as a means of improving organic synthesis. In recent years, the rapid development of biological simulation of polyene ring closure for the steroid provides a lot of full synthetic route. It breaks through the general synthesis of the synthesis of the ring-by-ring process, but rather the stereospecific formation of several rings by a straight-chain compound with a properly positioned trans-olefinic bond, not only in the theoretical sense but also in Practical will also have great value. Cholesterol and its metabolites are one of the basic substances in the life process, which has long been known. Cholesterol biosynthesis, which starts with acetate ions, is one of the most significant achievements of contemporary chemistry (Figure 1). Among the entire route, squalene enzyme