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性别的差异或生理状态下性激素水平的改变均可致多种免疫功能的异常。性激素在临床上已用于治疗多种疾病,评价其本身或其衍生物对机体长期应用的影响已成为十分重要的问题。作者利用血红蛋白酶释放法和 Cr~(51)释放法分别检测了性激素对小鼠脾脏抗体依赖性细胞介导的细胞毒作用(ADCC)和自然杀伤细胞(NK)活性的影响。将雌、雄激素临床常用量换算成小鼠给药量,隔日注射给津白3号小鼠,共给药2～6周,测其ADCC 和 NK 活性的同时还将分离到血清和脾细胞被动转移给正常小鼠,24小时后测定转移鼠的细胞毒活性。效应细胞分离后进行体外试验,分为用雌、
Sex differences or physiological changes in the level of sex hormones can cause a variety of immune dysfunction. Sex hormones have been clinically used to treat a variety of diseases and evaluating the effects of itself or its derivatives on the long-term use of the body has become a very important issue. The effects of sex hormones on antibody-dependent cell-mediated cytotoxicity (ADCC) and natural killer (NK) activity in spleen of mice were examined by hemoglobin release assay and Cr (51) release assay. The estrogen and androgens commonly used in clinical dosage converted to the amount of mice administered injection of Jinbai 3 mice every other day for a total of 2 to 6 weeks to measure the activity of ADCC and NK will also be separated from serum and spleen cells Passive transfer to normal mice, 24 hours after the determination of the cytotoxicity of metastatic mice. After effector cells were isolated in vitro tests, divided into female,