In this study, nanohydroxyapatite/polyurethane(nHA/PU) composites with various contents of methoxypoly(ethylene glycol) modified nHA(0 wt%, 10 wt%, 20 wt% and 30 wt%) were prepared by solution blending process. The physicochemical properties of the composite membranes were investigated by Fourier transform infrared spectroscopy(FTIR), X-ray diffraction(XRD), Transmission electronic microscopy(TEM), Differential scanning calorimetry(DSC), Thermo gravimetric analysis(TGA) and tensile tests. TEM photos of the nanocomposites showed that the nHA was uniformly dispersed in the polymer matrix. The membrane with 10 wt% nHA showed the highest tensile strength which was about 75% higher than that of the pure PU membrane. However, the tensile strength decreased when high content(above 20 wt%) fillers were added, which was still higher than that of pure PU. TGA measurements suggested that the thermal stability of the membranes was improved owing to nHA fillers. XRD and DSC results illustrated that the crystallinity of PU soft segments decreased with the increasing content of nanoparticles in the composites. In this study, nanohydroxyapatite / polyurethane (nHA / PU) composites with various contents of methoxypoly (ethylene glycol) modified nHA (0 wt%, 10 wt%, 20 wt% and 30 wt%) were prepared by a solution blending process. properties of the composite membranes were investigated by Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), Transmission electronic microscopy (TEM), Differential scanning calorimetry (DSC), Thermo gravimetric analysis (TGA) and tensile tests. of the nanocomposites showed that the nHA was uniformly dispersed in the polymer matrix. The membrane with 10 wt% nHA showed the highest tensile strength which was about 75% higher than that of the pure PU membrane. However, the tensile strength decreased when high content (above 20 wt%) fillers were added, which was still higher than that of pure PU. TGA measurements suggested that the thermal stability of the membranes was improved due to nHA fillers. XRD and DSC results illustrated the crystallinity of PU soft segments decreased with the increasing content of nanoparticles in the composites.