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采用切断兔眼部分睫状后短动脉造成脉络膜缺血的动物模型，测定脉络膜血栓素Ｂ２、（ｔｈｒｏｍｂｏｘａｎｅＢ２，ＴＸＢ２）和６－酮－前列腺素Ｆ１α６－ｋｅｔｏ－ｒｏｓｔａｇｌａｎｄｉｎＦ１α，６－ｋｅｔｏ－ＰＧＦ１α）的含量，并观察复方樟柳碱１号（ｃｏｍｐｏｕｎｄａｎｉｓｏｄｉｎｅＩ，ＣＡＩ）对其影响。结果表明，缺血１ｈＴＸＢ２及６－ｋｅｔｏ－ＰＧＦ１α升高；２４ｈ时６－ｋｅｔｏ－ＰＧＦ１α已呈下降趋势而ＴＸＢ１α仍处于较高水平，使ＴＸＢ２／６－ｋｅｔｏ－ＰＧＦ１α比率升高。ＣＡＩ号升高６－ｋｅｔｏ－ＰＧＦ１α并保持ＴＸＢ２和６－ｋｅｔｏ－ＰＧＦ１α之间的平衡。结果提示，缺血１ｈＴＸＢ２和６－ｋｅｔｏ－ＰＧＦ１α之间的平衡发生变化；ＣＡＩ号改善缺血区脉络膜的微环境并可能调节缺血区血管紧张度。
The animal model of choroidal ischemia caused by the short posterior ciliary artery was cut off and the contents of chorothrombin B2 (thromboxaneB2, TXB2) and 6-keto-prostaglandin F1α6-keto-rostaglandinF1α and 6-keto-PGF1α , And observe the compound anisodine I (compoundanisodineI, CAI) on its impact. The results showed that ischemic 1hTXB2 and 6-keto-PGF1α increased; 24h-6-keto-PGF1α had a downward trend while TXB1α still at a high level, so that TXB2 / 6-keto-PGF1α ratio increased. CAI increased 6-keto-PGF1α and maintained a balance between TXB2 and 6-keto-PGF1α. The results suggest that the balance between ischemic 1hTXB2 and 6-keto-PGF1α changes; CAI improves the microenvironment of the ischemic choroid and may regulate the ischemic vascular tone.