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用放射免疫法测定了76例窒息儿及53例正常新生儿血浆 ET-1浓度。结果正常新生儿生后血浆 ET-1随日龄增长呈下降趋势。重度窒息急性期血浆 ET-1明显高于轻度窒息及对照组(P<0.01),恢复期降至正常水平。轻度窒息与对照组比较无显著差异。表现中重度缺氧缺血性脑病(HIE)者血浆 ET-1明显高于轻度 HIE 及对照组(P<0.01),且头颅 CT 显示脑损伤者明显高于 CT 正常者(P<0.001)。轻度 HIE 与对照组比较无显著差异。提示 ET-1参与新生儿窒息的病理生理过程,与窒息程度及窒息后脑损伤有密切关系。
Radioimmunoassay was used to determine plasma ET-1 concentrations in 76 asphyxiated children and 53 normal newborns. Results The plasma ET-1 level of normal newborn babies decreased with the increase of age. The level of plasma ET-1 in severe asphyxia group was significantly higher than that in mild asphyxia group and control group (P <0.01), and the recovery time was reduced to normal level. Mild asphyxia compared with the control group no significant difference. The plasma levels of ET-1 in patients with moderate and severe hypoxic-ischemic encephalopathy (HIE) were significantly higher than those in mild HIE and control subjects (P <0.01), and the head CT showed that the brain injury was significantly higher than those with normal CT (P <0.001) . There was no significant difference between mild HIE and control group. It is suggested that ET-1 is involved in the pathophysiological process of neonatal asphyxia, which is closely related to the degree of asphyxia and brain injury after asphyxia.