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[目的]探讨联合监测血管内皮功能[内皮素(ET-1)、一氧化氮(NO)]及D-二聚体(D-dimer)对脑梗死患者诊断的临床意义。[方法]选择150例发病24h内的脑梗死患者,100例健康对照组,采用全自动生化分析仪和ELISA法分别检测内皮功能[NO,ET-1]和D-二聚体含量。[结果]脑梗死患者血浆ET-1、D-二聚体含量明显增高,NO含量明显降低;与健康对照组比较,差异有统计学意义(P﹤0.01)。[结论]脑梗死患者NO生成减少,ET-1生成增加,从而促进血管内血栓形成增加脑梗死发生的危险性;而脑梗死早期血浆D-二聚体明显升高,三者联合检测可为脑梗死的早期诊断和预防性治疗提供可靠的依据。
[Objective] To explore the clinical significance of combined monitoring of endothelial function (ET-1, NO) and D-dimer in the diagnosis of cerebral infarction. [Methods] 150 patients with cerebral infarction within 24 hours of onset and 100 healthy controls were enrolled in this study. Endothelial function (NO, ET-1) and D-dimer were detected by automatic biochemical analyzer and ELISA respectively. [Results] The levels of plasma ET-1 and D-dimer in patients with cerebral infarction were significantly increased, and the content of NO was significantly decreased. Compared with healthy controls, the difference was statistically significant (P <0.01). [Conclusion] NO production is decreased and ET-1 production is increased in patients with cerebral infarction, thereby promoting the thrombosis increased the risk of cerebral infarction. However, the plasma D-dimer in early stage of cerebral infarction is obviously increased, Early diagnosis and preventive treatment of cerebral infarction provide a reliable basis.