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1966—1968年,Pearse首先提出了关于APUD系—神经内分泌细胞组织的概念;这个组织的基本属性就是生物胺前体的摄取及其后的脱羧作用,并产生生物胶和多肽激素。目前,这一概念已引起众多研究者的注意,并且在生物学和医学的一系列基本问题中占有地位。现在,世界上几十个实验室正在卓有成效地研究这个问题,专论性文章的数量正在增长。已积累在正常和各种极端状况下APUD系细胞及其产物的多种多样作用的资料。本文就是力图使专家们了解这一概念的现状。
From 1966 to 1968, Pearse first proposed the concept of APUD-neuroendocrine tissue; the basic attributes of this tissue are the uptake of biogenic amines and subsequent decarboxylation and the production of biogels and peptide hormones. At present, this concept has attracted the attention of many researchers and holds a place in a series of basic problems in biology and medicine. Nowadays, dozens of laboratories in the world are studying the issue very effectively, and the number of monographs is on the rise. Has accumulated a wide range of data on APUD lineage cells and their products under normal and various extreme conditions. This article seeks to make experts aware of the current state of the concept.