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本文报道了一种在阿斯匹林和缓冲阿斯匹林制剂中同时测定阿斯匹林和非阿斯匹林水杨酸盐的改良USP法。在一氯化铁-脲素硅藻土柱上络合非阿斯匹林水杨酸盐,同时收集阿斯匹林洗脱液及其络合的非阿斯匹林水杨酸盐洗脱液,用分光光度法分别在278毫微米和306毫微米处测定其吸收值,然后按下列公式计算: 此处C为浓度;Au和As分别为试样配制液和标准液的吸收值;AW为平均片重;W为试样配制液的样品重。本改良法的效果是分析时间较短,为一个对阿斯匹林具指示稳定性的分析法,与
In this paper, we report an improved USP method for simultaneous determination of aspirin and non-aspirin salicylate in aspirin and buffered aspirin preparations. Non-aspirin salicylates were complexed on a ferric chloride-urea diatomaceous earth column while elution of aspirin eluate and its complexed nonaspirin salicylate The absorbances were measured spectrophotometrically at 278 nm and 306 nm, respectively, and then calculated as follows: where C is the concentration; Au and As are the absorbance of the sample preparation and standard solutions respectively; AW W is the sample weight of the sample preparation solution. The effect of this improved method is to analyze the analysis of a short time, as an indication of the stability of aspirin, and