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血卟啉衍化物(HPD)及新近提纯的双血卟啉乙酯(dihematorphyrin ether DHE)能选择性存留于恶性肿瘤及病毒引起的乳头状瘤内,经紫外线激活后能发出荧光,可用于区别肿瘤与正常组织。惟其判断具有主观性,其与以DHE为光敏剂,经适当波长的光激活后,多认为能选择性地杀伤变形的肿瘤细胞间的关系,但尚未证实。为此,作者进行了动物实验,以~(111)铟标记双血卟啉乙酯(~(111)In-DHE)后,分别注入3只由病毒诱发致皮肤乳头状瘤的兔及1只正常兔体内,用药3、16、27、39小时后,以大视野小摄影仪检测动物体内~(111)In的活
Hematoporphyrin derivative (HPD) and newly purified dihematorphyrin ether (DHE) can selectively remain in malignant tumors and virus-induced papilloma. After activated by ultraviolet light, they can fluoresce and can be used to distinguish between them. Tumor and normal tissue. However, its judgment is subjective, and it is believed that DHE is a photosensitizer and is activated by light of an appropriate wavelength, and it is believed to selectively kill the deformed tumor cells, but this has not yet been confirmed. To this end, the authors conducted an animal experiment to inject (111) In-DHE with ~(111)-indium-labeled dihematoporphyrin ethyl ester and injected 3 rabbits with cutaneous papilloma induced by virus and 1 In normal rabbits, the activity of ~(111)In in animals was detected with a large field camera at 3, 16, 27, and 39 hours after administration.