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目的:探讨心肌肌钙蛋白I(cTnI)、心肌肌钙蛋白T(cTnT)、肌酸激酶同工酶(CK-MB)的变化和老年心肌梗死(AMI)患者心肌梗死范围的相关性。方法:回顾性分析2012年9月至2013年9月于我院内科住院的80例老年心肌梗死患者的临床资料,分析治疗前和治疗1周后cTnI、cTnT、CK-MB值与心肌梗死范围的相关性。结果:与治疗前比较,治疗后患者cTnI[(4.63±0.21)μg/L比(0.15±0.03)μg/L]、cTnT[(0.71±0.05)μg/L比(0.17±0.01)μg/L]、CK-MB[(40.21±2.13)U/L比(23.32±2.11)U/L]水平显著下降,心肌梗死面积[(35.25±4.65)mm2比(23.17±3.76)mm2]显著减小(P均<0.01);Pearson相关分析显示,cTnI、cTnT及CK-MB与心肌梗死面积均呈显著正相关(r=0.99、0.98、0.95,P均<0.01)。结论:肌钙蛋白I、心肌肌钙蛋白T、肌酸激酶同工酶与心肌梗死范围关系密切,这三个指标值的结合可作为判断老年心肌梗死患者心肌梗死范围的重要依据。
Objective: To investigate the relationship between the changes of cardiac troponin I, cTnT, CK-MB and myocardial infarction in elderly patients with myocardial infarction (AMI). Methods: The clinical data of 80 elderly patients with myocardial infarction hospitalized from September 2012 to September 2013 in our hospital were retrospectively analyzed. The changes of cTnI, cTnT, CK-MB and the extent of myocardial infarction before and after 1 week of treatment were analyzed Relevance. Results: Compared with those before treatment, the cTnI levels of cTnI [(4.63 ± 0.21) μg / L vs 0.15 ± 0.03 μg / L cTnT [(0.71 ± 0.05) μg / L vs ], CK-MB [(40.21 ± 2.13) U / L ratio (23.32 ± 2.11) U / L] and myocardial infarct size [(35.25 ± 4.65) mm2 vs (23.17 ± 3.76) mm2] P <0.01). Pearson correlation analysis showed that there was a significant positive correlation between cTnI, cTnT, CK-MB and myocardial infarct size (r = 0.99,0.98,0.95, P <0.01). CONCLUSION: The values of troponin I, cardiac troponin T and creatine kinase isoenzyme are closely related to the extent of myocardial infarction. The combination of these three indexes can be used as an important basis for judging the extent of myocardial infarction in elderly patients with myocardial infarction.