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目的:探讨八正颗粒联合左氧氟沙星对单纯性急性尿路感染血清降钙素原(PCT)、白细胞介素-8(IL-8)水平及临床疗效的影响。方法:选取我院泌尿科收治的单纯性急性尿路感染72例,随机分为对照组和观察组,每组36例。对照组患者予以左氧氟沙星治疗,观察组患者在对照组基础上予以八正颗粒治疗。观察并记录两组间血清降钙素原(PCT)、白细胞介素-8(IL-8)水平、症状改善时间、临床疗效及不良反应的发生情况。结果:对照组治疗有效率为72.22%,显著低于观察组(91.67%),差异具有统计学意义(P<0.05);观察组尿路疼痛、腰痛、尿频、尿急等症状改善所需的时间均明显短于对照组,治疗后血清PCT、IL-8水平显著低于对照组,差异均具有统计学意义(P<0.05)。结论:八正颗粒联合左氧氟沙星治疗单纯性急性尿路感染的临床效果较单用左氧氟沙星治疗更好,且能有效降低患者血清PCT、IL-8水平。
Objective: To investigate the effects of Bazheng granule combined with levofloxacin on serum procalcitonin (PCT), interleukin-8 (IL-8) levels and clinical efficacy in patients with simple acute urinary tract infection. Methods: Seventy-two cases of simple acute urinary tract infection admitted to our hospital for urology were randomly divided into control group and observation group with 36 cases in each group. Patients in the control group were treated with levofloxacin, and patients in the observation group were given Bazheng granule treatment on the basis of the control group. The levels of serum procalcitonin (PCT), interleukin-8 (IL-8), symptom improvement time, clinical efficacy and adverse reactions were observed and recorded. Results: The effective rate of the control group was 72.22%, which was significantly lower than that of the observation group (91.67%), the difference was statistically significant (P <0.05); the urinary tract pain, back pain, urinary frequency, Time were significantly shorter than the control group after treatment serum PCT, IL-8 levels were significantly lower than the control group, the difference was statistically significant (P <0.05). Conclusion: Bazheng granules combined with levofloxacin treatment of simple acute urinary tract infection clinical efficacy than single levofloxacin treatment is better, and can effectively reduce the serum PCT, IL-8 levels.